Mills et al.’s paper, “Comparative effectiveness of dual-action versus single-action antidepressants for the treatment of depression in people living with HIV/AIDS” (2017) evaluates the difference between dual- and single-action antidepressants in patients with HIV/AIDS by analyzing remission rates from both types of medication. Depression is a common comorbidity associated with developing HIV/AIDS. The authors used data from Centers for AIDS Research Network of Integrated Clinic Systems to analyze 1175 patients treated with dual- and single-action antidepressants. Mills et al. concluded there was no significant difference in double- and single-action antidepressants. While both types of antidepressants resulted in few cases of remission, a revaluation of treatment is needed to provide full remission